I'll offer an opposing, somewhat unpopular, opinion.
In a Strat bridge position, I think the Lil' 59 really bad, perhaps my least favorite pickup ever. It's lacking in harmonic richness as compared to a full size humbucker, especially in the upper mid ranges. This results in it not doing well in a typical band stage mix without some help from creative EQ-ing. Split, it's pretty useless, weaker sounding that a regular Strat bridge. I've seen a number of people struggle trying to get this pickup to work for them. It did OK when playing at home alone but really fell apart in a live band situation and required a lot of tweaking to get it to work when recorded.
A 2000 American Deluxe Strat probably has a swimming pool rout (check to make sure). If so, you could swap in a new pickguard with a full size HB bridge and single coils that complimented it while putting your original guard aside intact.