I'm a big fan of a low output (i.e. vintage type) humbucker in the neck. That, plus a single coil in the bridge, is my go to PU combination on a Telecaster. Oh, but I should say I LOVE the regular Tele neck pickup, too!
There are things I like about all configurations. But, just talking Tele here, I still like two single coils.
I like Tele neck pickups, but after trying a low-wind P90 (still single coil) in the neck of my Tele, I really like the way it "grunts" and warms up the neck and middle switch positions. I'm not wiring it to the tone pot so it retains some brightness which I like. Pairs great with a Cavalier Fat Lion or other slightly hot Tele bridge pickup. Very smooth with added gain.
I've probably posted too many pictures of it, but... any excuse: