For gigging I could strip it down to:
Partscaster Strat with mid boost.
Marshall SV20h and cab.
JHS Black box in the loop to act as a master volume.
Mic & stand for vocals into our PA.
This would involve more fiddling about between songs (or maybe change the running order a bit) rather than how I currently run with the amp set clean and using pedals for dirt/solo boost and a vocal pedal for a bit of reverb/compression:
This is more typically what I gig with, so I add the P90 Gibson LP, plus the pedal board, mainly just to have a back up guitar and easier sound selection, so we can keep going straight into the next song without too much hanging around if I have to fiddle about with settings.
One time I did finish a gig with just my Strat into my Fender Deluxe after the pedalboard failed mid gig. It was OK, but some songs really needed a bit of dirt and many of our smaller UK venues mean I can't just crank the amp for dirt tones.