Sometimes I wonder how much of a role expectations play in the guitar tones we hear. I'm a firm believer in pickups being the largest contributor to electric guitar tone with body type, (Solid, Semi-Hollow and Hollow), probably being the next followed by bridge / tailpiece types. Sure. Everything else contributes in one fashion or another. Types of wood used. The material for the nut and saddles. Internal electronics. Fret and String types, (metals utilized, size, thickness and construction). You can drive these into the slightest of tonal variations when you start including glue, binding, inlays, etc. etc..
In my opinion a big reason a Telecaster sounds like a Telecaster is because we see a Telecaster and our mind immediately puts us on a path to hear Telecaster tone. Yet, even with that mental expectation a set of pickups can completely cave that expectation and take us to tones our minds would have never expected. On an Electric guitar pickups are the first stop shop for tone.
Note* I've found that leaving the plastic back plate off the Stratocasters rear tremolo cavity will cause the middle pickup to adjust in a way that adds more air and reduces glassiness when in the 2 or 4 switch position on a Strat. Of course we're talking about Telecaster tone so that observation holds no water in this discussion.
And don't get me started on 1, 3, and 5 ply pick guards.