I'm kind of from the Jimi/SRV school of Strat. I'm all over the pickups and vol. Tone, quite often on the bridge (I always make sure that I have a bridge-only tone).I don't tend to change pickups much or at all mid-song, preferring to increase the volume instead of needed, or step on a boost pedal, or just pick harder (usually). I mostly change pickups when I want a different attack. I will sometimes play a song with the pickup switch in middle position and then change to the bridge for the solo if I want that sharp attack.
To me a strat is already confusing, so having thee MVs would not work. At all. But we all have different approaches.