The necessity of using a buffer at the start of one´s signal chain is often discussed. More or less incidentally I found out what a difference a buffer can make. I didn´t believe it would be a big difference because my cables are short and the signal runs only through three or four pedals, all with true bypass. Then I read how to switch the first pedal between buffer and true bypass and just wanted to try it out. I had to notice that the difference was tremendous. I noodled two chorusses of a blues bt, changing pickups within one chorus; please pay no attention to the playing, it´s ...! The signal chain is: American Standard (Twisted Tele / Broadcaster pickups) => Source Audio Programmable EQ => Source Audio Gemini chorus => TC Flashback => Lonestar Special 2x12. The only difference in sound between the two chorusses is if the EQ´s buffer is activated or not. Of course I can´t say that the difference is the same with other guitars, cables or pedals. But if you think your sound is too muddy, buffering might help. If your sound is too bright, using no buffer might help.