This assumes you have a Tele with the neck pickup mounted to the body. Most of mine have not have it mounted to the body. ...But since I have both, I'd say it's actually not much of a sonic difference. The body mounted Tele neck pickup is more of a sort of quasi-convenience, as the neck pickup height can be adjusted independently of the pickguard itself, so IMO it becomes more of an aesthetic thing, if I care to swap out the pickguard w/o having to screw with the neck pickup. Having said that, the vast majority of guitars seem to have the neck pickup either mounted in something like a mounting ring, or within the pickguard. So I'm used to being able to adjust the neck pickup w/o having to remove the pickguard just to adjust the neck pickup height, for that reason.