It never ceases to amaze me, and I was reminded of it tonight - what might seem to be a small setup adjustment can make a huge difference. I have a Tele that I had raised the action on some time ago. I was playing it earlier this evening and I noticed that even though there were no strings buzzing, it just kind of went 'thud'. No spank/liveliness/zing. I looked closer and decided the action was probably too high. I looked further and realized there was too much relief in the neck. A quarter turn of the truss rod later and a very minor tweak on the saddles, and it's an entirely different guitar. Total transformation. It was twanging more like a Tele should, it felt and played more "right", and it just sounded better overall. I know this seems like an obvious point to make and maybe even a waste of a post, but it's just a reminder that it's the small stuff that can make a big difference.