Haloskater, compare the schematics of the 5F8A and the 5G13. There are great differences in how those two preamps are built, and yes the preamp is a big part of Determining what an amp does. The outputs are much more similar. You are going off into amp design. I am not an amp designer, but I am going to think that one would want and need to know what the goal was in order to put together a circuit that would do that.
What amp have you played or heard that attracts you? If you want the harmonic trem, then I would strongly suggest that you use one of Leo’s circuits and stay true to it as much as possible until you get it working. Then, perhaps you could shape certain aspects to your liking. Less or more midrange? Less or more negative feedback?? The number of power tubes is not a major deal....if you want that 80-100 watts of power for some reason, then make sure the power tranny can handle the tubes’ demands and build with an OT that does what you want there. If you want a big 5E3, then build a 5E5A. Imho, the 5E3 circuit is alone in the tweed era from 1955 through 1960. If you want a 5F6A thing, then build that or a 5F8A. The 5E5A,5F4 and 5E7 amps are a subgroup of their own in that era of tweeds. the Champ/Princeton are a Subgroup, and the Tremolux and Vibrolux are a subgroup. The 6G era has maybe three subgroups of guitar amps....those with harmonic trem and complex tone controls are in one group, those with bias vary trem and two knob tones stacks, and the Deluxe and Princeton with bias vary and single tone controls. The BF era of guitar amps saw one basic preamp with a difference in the type of trem...bias vary versus opto-isolator.
What do you like to hear and play??? That is the question I have to ask and answer when I want another amp.