I've used them in the past thru a clean amp and boosted them with a tube screamer when i want hi gain. But one thing i never did was run overdriven amp thats driven to about 1/2 the OD i want and use the RAT to add the other 1/2. Or maybe 70/30 or 60/40 etc, but you get the idea. Do any of you run them like that? Possibly like a tube screamer where u set the volume up and distortion down to drive the input of the amp into higher OD? Or do you all just use the RATs OD into a clean amp? I like that but the way i plan to run it (Biyang DS-8 in the mail) Is amp a bit cleaner then i want and RAT as clean boost to add more heat. I have tube screamers i'm using like that but i figured i'd like to have a RAT and use it the same way to have a different flavor then the TS. And also to occasionally use it into a clean amp like i used to and hit the RAT with a tube screamer for singing stuff. That right there is worth the price of admission! But rthat alone isn't what i bought it for o just wanted to see if anyone runs thiesr the way i mainly plan to.