Also the neck, bridge and neck and bridge pickup pickup change things fundamentallyNot really. Theresa a range of tones, from The country guys to the soul guys to the rock guys to the jazz guys. Within there there’s a trebly space thing. But apart from that a Springsteen versus a cropper vs gatton vs mike stern?
Listen to the guitars on the Nick Mason's Saucerful of Secrets live album. Everything from the Syd era is played on Telecasters, the later stuff is Strats, and to me at least the difference is very clear. So the clanging guitar sound on Interstellar Overdrive, Arnold Layne, Lucifer Sam, See Emily Play, Vegetable Man -- that's a great example of a typical Tele sound (though very far from being the only sounds if can make).