I've had teles with three saddles, six saddles, brass, steel, whatever.
Amazingly, every guitar sounded like a tele. Current #1 is a Kirn. It sounds like a tele. A really, really good tele. That one has a Gotoh bridge with brass compensated saddles. It works. I really don't know what the percentage contribution of each component (pickups, electronics, bridge, saddles) is, but I've had a lot of teles in a lot of configurations, and they all worked!
Kirn guitars are a treat in the pictures on his site. Beautiful work.