Being a tinkerer from way back, I've tried Duncan, Dimarzio, Fralin, Fender, Lollar, Rumplestilskin, Bootstrap, Stewmac, Tone Hatch, GFS, Gibson and probably a dozen other makers. Only a few fell short of expectation and coincidently came from the makers of some of my favorites. When I cobbled together my first Strat I put a set of Fralin Blues Specials in it since I really liked those pickups in a 70s Strat I had. I played a gig the day I installed them and found my sound pretty brittle and disappointing. I swapped them out with a set of Fralin Real 54's and voila, my favorite guitar ever.
Lots of good options out there that fit budget and expectations. But, like mama said, box of chocolates and all that stuff.