I’m not sold on any 1 gauge of string. Some guitars just seem to setup or play better with different gauges. I like 11’s on my fender guitars, but I have one partscaster strat that would setup better with 10’s, so that’s how I keep it. I’ve got 12 gauge flat wounds on a 335 for finger style jazz (not much bending!) and round wound 10’s on another 335 which I like for funky bluesy stuff. I like being able to mix it up when I feel like it. As far as string gauge affecting the tone... its just another tiny variable.