Ok, I've been whacking myself over the head for 3 hours trying to figure this out.... Trying to keep it short, but may not be able to: I had a Fender Mustang 2 and a Katana 50w They seemed kind of redundant, so I loaded them in the car, went to Guitar Center and traded both (plus some cash) for a 100 watt Artist series. Love the amp... here is my only issue. When I had the Katana 1 and Mustang... I had one 15 foot USB extension cable and just swapped out cables as needed..... I'm anal about cables running across my room, so I bought USB over Cat5 adapters... Ran it over a flat 20 foot cat5 cable.... And both worked perfectly...So I replaced my base moulding and routed a channel in it for the cat 5 run... Post moulding swap... Both amps worked and connected perfectly to my computer... So I bring home the artist series, plug it into the same spot where the old Katana was... Nothing. I finally move the new amp closer to my computer, and plug it directly into the computer with just the USB cable (bypassing the USB over Cat5 run)... Works fine... load new firmware, software etc..... Should be in business now right? Nope.... WTF??? I ended up going across town and borrowing a buddy's Katana 1..... Plugged it into my cat5 extension......and it worked fine..... Plug the Artist back into the same run.... Nothing!!!! How in the hell is this possible? What could I possibly be missing? So much for keeping it short... If you got this far, Thanks in advance for any insight.