I do an acoustic thing that involves a lot of different alternate tunings. Changing tunings in the middle of a set was sloppy showmanship so I had a "quasi-acoustic" guitar built. It looks and feels like an acoustic but it has a Ghost Hexpander MIDI system that I run through either a Roland VG8ex or a Boss GP10. The acoustic patches are pretty decent but the surprise was some of the electric patches, especially the "Keef" 5 string Tele patch. It sounded great but the guitar is strung with light gauge phosphor bronze, too heavy for the right "feel" for electric. Conversely, I find that piezo pickups on an electric don't sound right acoustically under the typical light gauge electric strings. Obviously I don't blend the analog and MIDI output when using an alternate tuning patch but I've never liked to blend them in a standard tuning either. I've considered putting the Hexpander system in my Tele but may just build another "partscaster" with only the Hexpander pickups.