I usually plug straight in. My amp is a Mesa Boogie F30 combo with a WGS Invader speaker. Sometimes I use a Sweet Baby overdive to get a different barely distorted sound. I might use a wah if I'm playing funk. I build my own fuzz pedals, so occasionally I'm in the mood for a fuzz face or a tonebender. I used to us them all the time before I had the boogie, but these days they rarely make an appearance. At this point I plug straight in to the amp 90% of the time.