The hard part, especially if your band plays a wide variety of stuff, and ESPECIALLY!!! if you sing at all is, getting the quick/abrupt clean to crunch and back transitions done accurately via just the guitar volume knob. Its damn hard. And it's why I prefer pedals live. Between my amp a dual OD and a clean boost, I have 6 different tones/gain levels. And if you use any pedals at all(verb/trem/delay/ANYTHING) you may as well just embrace the fact that you're not plugging straight in. That said, i plug straight in WHENEVER I CAN. And i think it makes me a better player. Especially my picking hand. At a minimum, more in tune with my amp and guitar. Theres nothing to hide behind, or cover up your playing. Not sucking plugged straight in is harder than not sucking thru 6 pedals.