I think this is the first thread ever where I "Liked" every post. To my shame, I have never read any Thompson, but I've read folks heavily influenced by him. Clearly, I need to make the time.
This is not one of his pithy little quotes, but I go back regularly to the passage in Fear and Loathing in Las Vegas, the "with the right kind of eyes, you can almost see the high water mark, that place where the wave broke and rolled back" chapter.
That's right up there in the 20th century American lit imo, with the final passage of the Great Gatsby. (The Great Gatsby which was a big influence on HST. He claimed to have typed it up.)
I have several favorites, most of which are unsuitable for posting here, but this passage from The Great Shark Hunt always stuck with me...
"...In a world as weird and cruel as this one we have made for ourselves, I figure anybody who can find peace and personal happiness without ripping off somebody else deserves to be left alone. They will not inherit the earth, but then neither will I... And I have learned to live, as it were, with the idea that I will never find peace and happiness, either. But as long as I know there's a pretty good chance I can get my hands on either one of them every once in a while, I do the best I can between high spots."