I did the reverse-angle experiment years ago with a Gibson Melody Maker and a Strat pickup, and it worked very well. That was a mids-heavy guitar as I received it, with a hacked-in Gibson humbucker. It already had a big ugly rout and a hacked-up pickguard, so I didn’t have much to lose. I liked the twangier low notes/warmer high notes a lot. Unfortunately the skinny little neck was pretty cramped for my bratwurst-looking fingers on the first few frets. But it did sound great.