Well, the story goes like this: Since about two years I regularly record me playing guitar along a backing track (TDPRI jam over in the Twanger Central). My gear is a Mesa Express 50 + with a Palmer 112 open back cab with a Cannabis Rex. During that time I used different mics, since some weeks a Mesa Cab Clone. I like the sound of the Cannabis Rex, but after recording I often used the DAW´s eq to dial in some more high mids in order to let the guitar cut through the mix better. So I thought, let´s try another speaker that has more of those high mids I was often looking for. On the base of a speaker comparison video I came to the conclusion that an Eminence Legend might be what I wanted and ordered another Palmer 112 with that speaker. It was delivered, and I plugged it into the Mesa. The first thing I learned that the Legend was less loud than the CR, but that was to be expected. I then found that with the clean mode the new cab sounded the way I wanted, the sound was more piercing. That was ok with the bridge pu, but the neck pu sound was less desirable. When I switched to the blues mode, I was terrified. That mode, which is more mid-orientated and sounded great with the CR, was somewhat etching with the Legend. Furthermore, the tone stack of the amp now seemed to influence the wrong frequencies. In the end, I use the cab with the Legend to bring the CR cab higher above ground so I can hear it better. This brought me to think about the interaction of pickups, amp and cab. I remembered that my 2010 Tele with stock pus sounded good in bridge position when I used the Tweaker (which is a more dark sounding amp), but bland with no balls and too much treble when the Mesa came in. I am still thinking about the fact that a sound I like when I hear it directly needs a little eq adjusting when recorded, or that the sound after eq adjusting appears disgusting when it comes out of the cab, respectively. Furthermore I came to the conclusion that different pickups surely affect the overall sound one gets, but that amp and a cab have a much bigger amount of effect on the overall sonic outcome than (relative similar) pickups. I decided now, that the combination of Mesa Express and Cannabis Rex is the right one for me to sit beside it. I will not try to change that unless I hear a better alternative standing in front of the gear and playing my guitar. If I will ever stand on a stage, and my guitar needs a high mid boost, well then are equalizers. Finally, I will never ever buy a pickup again on the base of hearing a video no matter how well it is produced, as long as they don´t use a Mesa Express with a 112 CR open back cab on that video. I would like to hear your experiences, especially on the question of guitar sound you hear when playing yourself and guitar sound when you take the perspective of the audience. And: where do you start when building your sound: guitar (pu), amp, cab?