For the past 7 years I've been working a job 65 miles from my house. As a result, I've put TONS of miles on my 2005 Toyota Sienna. As of this morning, I've got 332,216 miles. The thing still runs like a champ, though. As a matter of fact, when it was in the 250k range, we drove it from Oklahoma to Maryland and back for a summer road trip, and I wasn't the least bit nervous. Sure it's got a few minor things going on now (driver's side door has to be unlocked with a key instead of the fob, passenger sliding door electric open/close doesn't work) but nothing that impedes its ability to function great as a means of getting me to/from work. I love this van and hope to get at least 500k out of it. So tells us about your high-mileage vehicle.