Most signature instruments are only distinctive to a pretty small segment of the musician community, and most have nothing about them beyond perhaps a discreet signature on the headstock that would clue in the average audience member, or even most musicians, that there's something special about that particular model. Les Pauls are in a little different category because that's a signature MODEL, not just a signature VERSION of an existing model. There are a few other models in that cagetory (like that angular hourglass Annie Clark model that Music Man makes) but for the most part you need to be a pretty serious gear geek to even realize that there's anything special about that particular Strat or whatever. (Side note: I've always thought it was funny that there are signature versions of signature models, i.e., a Jimmy Page Les Paul. I seem to recall that at one point Pete Townshend was playing an Eric Clapton Strat on stage with the Who. I was hoping that Fender would put out a Pete Townshend Eric Clapton Strat.) There are a few sig models that replicate the look of very distinctive trademark guitars, and those are in a slightly different category---like an SRV Strat that looks just like his number one, or a dragon Jimmy Page Tele, or a Joe Strummer Tele, or that Hendrix Strat pictured above. The Brad Paisley Teles might fall into that category too. But most signature guitars don't scream "signature" from any distance. Again, you'd need to be a pretty serious gear geek to notice that a Mark Knopfler Strat, or a Clapton Strat, or an Eric Johnson Strat, or a Jeff Beck Strat, or a Jimmy Vaughn Strat, etc. was anything out of the ordinary. There are guitars that have subtle configuration differences that would be a giveaway to the discerning eye, i.e., the humbuckers on the Chris Shiflett Tele or the modified controls on the Johnny Marr Jaguar, but on the whole even stuff like that is pretty subtle. I might be a little reticent about playing a guitar that was an obvious visual recreation of a very distinctive instrument associated with a particular artist, but I wouldn't be concerned that a guitar I otherwise liked was a signature model. I would not want to have to pay a big premium for the signature, but if it's reasonably priced for what it is I would not avoid it just because it's a sig, even if it was a sig of somebody unrelated, or even antithetical, to the music I play. (I'm a big fan of Les Paul (the guitarist), and look how far afield his signature guitar has gone, compared to what he played on it!) Having said that, I can't think of any signature guitars that are currently giving me GAS, but, I would not mind at all having a Geddy Lee Jazz Bass. It looks pretty similar to a regular Jazz Bass (the block inlays and Badass bridge would be the giveaways), but it has a different neck profile that AFAIK is not available on any other Fender bass, which I really like.