I'm curious what any and all of you who deal with some kind of hand issue (like a pain or medical issue) and what specs on necks and whatnot have worked for you. I know its going to be different for everyone. Me, I have carpal tunnel. I wear braces at night that have helped tremendously, though I suspect I'll need the surgery one day. I don't have it from guitar playing, rather, I sleep funny. But guitar playing can aggravate it and it can make guitar playing hard. I focus a lot more on proper posture and hand position and technique than I used to- also a help. Anyway, I'm mostly playing a standard fender tele and strat these days- the 9.5 radius, "modern C" and all that. I'd like to add a 24.75 guitar. I wonder if that will have any effect on the hand or wrist. I suspect no. As for radius, I'm not sure what would affect what. For neck profile, I tend to like thicker- a little more relaxed and natural for me. Not that what I own are all that big or anything. Anyway, what issues have you had and what specs have you found have helped you, or not helped you?