Some Drilling Questions

What holes do I NOT drill before spray finishing? How tight should the hardware such as screws and tuner bushings fit to avoid wood stress/cracking but at the same time ensure the screws and bushings stay in place? Would I get best results if drilling with hand crank drill, electric drill, or dremel? Do I need to ensure some lacquer makes it into the drilled holes to seal out moisture (& beer spills) for the longer term? I'm building a tele and have the unfinished maple neck & ash body (both are from USACG for a Blackguard style guitar). Certain holes were already predrilled from USACG (neck pocket holes, bridge holes, jack, string ferrule holes, tuner bushing holes, etc). The holes I need to drill are: tuner screw holes, pickguard screw holes, control plate screw holes, strap button holes, electrosocket holes. Most guys say to drill holes before spraying, and I'm wondering if there are some holes that I should NOT drill until after spraying. Whether I drill before or after, I assume the holes should be drilled loosely enough so that I can tighten the screws down using only two fingers with the screwdriver (as opposed to needing my whole hand to crank down the screws), right? I've already sanded out the tuner bushing holes and they fit in loosely (can lightly tap them in with my pinky finger) but still don't fall out on their own. Does that sound right, or did I mess up the bushing holes? I assume hotter weather will expand the wood/bushings which could crack the wood if the holes are too small (also assume after spraying the wood that the holes will be tighter and also that the wood will dry out & shrink over the years possibly causing cracks). I'll wet sand using naptha instead of water to avoid wood swelling. Lots of questions but I figure this is the right place to ask. Thanks.

Sounds like most of your holes are already drilled. I wouldn't drill pickguard holes until you're assembling the guitar. Water is fine for wet sanding just keep it out of any holes. Water in screw holes can make the wood swell a spoil your perfect finish.