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In my limited experience, it really depends on the amp. Some builders voice amps in a certain ways, have a V1 tube in mind for that sound. By all means experiment, and see for yourself. I tried it recently with a SR and VR. Pulled V1 (to subtly boost gain in the reverb channel), then tried a 5751. Me, I preferred them that way, a little less volume, a little more headroom and clarity in the middle volume ranges. But the guy who owns the amps liked the 12ax7 in there much better.
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