I do it quite often. My ESP came, factory setup, a half-step down. I readjusted the Floyd Rose
, truss and intonation to standard tuning, but it never sounded quite right. I readjusted everything back and it was perfect again. I don't know if it's the pickup winding or what. It never sounded right tuned standard. Now, I just use my Fernandes Tele copy to learn material at different tunings. It never causes a fuss.
I have an Ovation with nylon folk strings that usually stays at Eb.
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What happens when you play at a jam with that guitar? I'd think that you'd just have to tell everyone else what key you're in etc. Does the Bass player necessarily have to tune his bass to Eb also?
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It would sound better! A good drummer will make the necessary tuning adjustments, too. If you are going to use drop tunings, everyone needs to do it for it to work right. I did it, in the past, when working with a lower, register vocalist. It does beef-up the bottom end some, but I prefer standard tuning.