I try to give em a chance. Sometimes it takes a while. My Stroup archtop has a much thicker neck than I'm used to, and I really thought I was going to have to sell it.
It sat in the case for about a year, but then one day I looked around and realized that it was my only electric that didn't need a setup or some kind of other work. I started taking it to practice, and before long I'd forgotten that it was hard to play- it just felt normal. Now it's here to stay.
But yeah, if it's just not working, there's not sense keeping it.