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Hmmmm, i'm always leery about QuickTime updates, that always seems a good way of spoiling an already running Mac.
But if you haven't done any updates maybe it's a 'preference' thing, turn off all your apps and Go>Home>Library>preferences and look for your Alesis pref file and put it in the wastebasket (don't empty it yet) then fire up something with audio, if it works now you can delete the pref file if not put it back.
Repair your permissions, sometimes my Mac just forgets how things work and rebuilding is a bit like the old 'Rebuild desktop' trick that points it in the right direction again.
Go>Utilities>Disk Utility>Highlight drive>click 'repair permissions'.
Good luck Woody !, you'll probably kick yourself when you figure it's something simple.
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