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Changing a "stock" tube to one of better quality will change the sound of your pre-amp. (After all, it's the tube that is amplifying the signal getting to the output stage).
However, whether it's very noticeable or not . . .
May also depend on your mic and other gear.
What type of tube is the original?
What mic/s are you using?
Are you mic'ing a guitar amp, or playing direct into the pre ?
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