After reading Lincoln Brewster's input on the Line 6 stuff I decided to try one out. So being the cheap man that I am I got a floor pod on the Bay and I am loving it. I don't usually change setups in the middle of a song, I run clean most times with a little reverb and use the foot pedal for a volume pedal instead of the wah. I love it, it really makes my tele sound good and my **ahem** strat sounds much nicer than running direct or even with effects pedals. I have not ran the Vox, but the line 6 is getting good reviews.
check it out.
http://lincolnbrewster.com/