I've got 4 Highway Ones, 3 Teles and One Stratocaster.
Based on the Wine Trans color (which replaced the trans red) we know your guitar is an "Upgrade", mid 2005 or later guitar. We know it has REALLY BIG frets and we also know it has the cheap die cast Fender/Schaller tuners made by Ping, overseas possibly in China.
I'm not sure if you are referring to fret buzz or if you are suggesting you have loose frets; I'll assume the former. I'd say it is quite hard to set up a guitar super low with such large frets without some inadvertent fret buzz. You gotta tolerate it, or raise the set up.
Or your could level the frets down to a normal size as I did on one Highway One, replace the neck with a big aftermarket fattie (normal frets) as I did on 2 others, a Tele and a Strat. My 4th Highway One is an earlier model with smaller frets, it is OK as it is.
Replace those cr@ppy tuners with some good Gotoh 'klusons' if you're getting the typical junky noises from there I remember.