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I've been playing guitar for over 25 years, and have probably used every brand and gauge of string there is...everything from 8s to 12s. I dont notice much difference in the tone. I choose the gauge based on the way they feel, and I buy Ernie Ball because I like the way the package looks. Flatwound strings will obviously sound different than roundwound, but unless you're playing jazz, you probably dont want those.
Really, the difference in tone between different brands and gauges is minimal. If you're looking for a certain tone, the important things are the guitar, amp and your technique.
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