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I think I remember this from physics. When electricity passes through a wire, a magnetic field is created. When two wires (conductors) are separated by a dielectric( air) capacitance is created. When electricity goes through a coil of wire, inductance is created. It would seem to me that the difference between the two systems of wiring would cause the sound to be different ( however subtlely) due to the proximity of the conductors to each other. The wire would also have different resistances due to their cross section. If one pickup can sound different from another by winding it differently, it would seem that one amplifier could too.
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